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2 drivers injured in head-on crash on SLO County highway

Two drivers were sent to the hospital with serious injuries after colliding head-on on Highway 166 on April 19, 2026.
Two drivers were sent to the hospital with serious injuries after colliding head-on on Highway 166 on April 19, 2026. Santa Barbara County Fire Department

Two drivers were sent to the hospital with serious injuries after a head-on crash late Sunday night in San Luis Obispo County.

The cars were driving toward one another in opposite directions on Highway 166 about one mile west of Highway 33 when they collided at around 11:10 p.m., according to a Santa Barbara County Fire Department post on X.

One driver was airlifted to Cottage Hospital in Santa Barbara with major injuries, while the other person suffered moderate injuries and was taken by ambulance to Marian Regional Medical Center in Santa Maria, the Fire Department said.

Two drivers were sent to the hospital with serious injuries after colliding head-on on Highway 166 on April 19, 2026.
Two drivers were sent to the hospital with serious injuries after colliding head-on on Highway 166 on April 19, 2026. Santa Barbara County Fire Department

There were no passengers in either vehicle.

The cause of the crash is under investigation, according to the agency.

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Hannah Poukish
The Tribune
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Hannah Poukish covers San Luis Obispo County as The Tribune’s government reporter. She previously reported and produced stories for The Sacramento Bee, CNN, Spectrum News and The Mercury News in San Jose. She graduated from Stanford University with a master’s degree in journalism. 
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