Update, 7:30 a.m.
A woman was killed and seven other people were injured as a result of the crash, the CHP said.
Highway 41/46 near the Shandon Rest Area was closed in both directions for about an hour and a half Tuesday night as emergency crews responded to the scene of a car crash.
A car reportedly rolled over and down an embankment, ejecting at least one person, according to Cal Fire and California Highway Patrol.
The patient was transported to a nearby hospital, according to the San Luis Obispo CHP Traffic Incident Information Page. Cal Fire reported multiple injuries.
This story will be updated as more information becomes available.