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SLO car crash injures 3 people, blocks traffic on Highway 101

Three vehicles crashed at the Los Osos Valley Road offramp of southbound Highway 101 in San Luis Obispo on April 25, 2025.
Three vehicles crashed at the Los Osos Valley Road offramp of southbound Highway 101 in San Luis Obispo on April 25, 2025.

A multi-vehicle crash injured three people and blocked traffic on Highway 101 through San Luis Obispo on Friday afternoon, the California Highway Patrol said.

A blue Nissan sedan, a Blue BMW and a blue Honda Civic collided at about 4:45 p.m. at the Los Osos Valley Road off-ramp for southbound Highway 101, according to the CHP traffic log.

Three people suffered injured mild to moderate injuries in the crash, according to emergency radio traffic.

As of 5:30 p.m., traffic was moved slowly in the southbound lane ahead of the collision, the Caltrans traffic camera showed.

Stephanie Zappelli
The Tribune
Stephanie Zappelli is the environment and immigration reporter for The Tribune. Born and raised in San Diego, they graduated from Cal Poly with a journalism degree. When not writing, they enjoy playing guitar, reading and exploring the outdoors. 
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