Dogs With Separation Anxiety May Find Relief With This New FDA-Approved Medication
As the dog mom of a fur child with fairly severe separation anxiety, I can tell you: it is not easy. He deserves to feel safe and secure, but mom also needs to go to the gym or grocery store without worrying sometimes! So, when I heard that the Federal U.S. Food & Drug Administration (FDA) has approved a new medication for the treatment of separation anxiety in dogs, I was definitely intrigued.
Here's what we know about the new FDA-approved medication.
What Is Tasipimidine Oral Solution (Tessie)?
Tasipimidine oral solution (brand name Tessie) was approved for the treatment of separation anxiety in dogs as well as noise aversion. While the FDA has previously approved medications for separation anxiety and noise aversion individually, this is the first mediation that has been approved by the FDA for both conditions.
Related: Can Dogs Develop Post-Traumatic Stress? An Expert Weighs In
Tessie's active ingredient tasipimidine is an alpha-2 adrenoceptor agonist, which works by by activating receptors in a dog's brain that lower their fight-or-flight activity in the sympathetic nervous symptom, which is associated with noise aversion and separation anxiety.
Tessie is usually administered to the dog orally one hour prior to the triggering event (i.e. fireworks or leaving the home). It should not be given with food, as this can delay the drug's absorption. Wait one hour before feeding after giving Tessie. That said, the FDA states a small treat may be taken with the mediation to ensure it's fully consumed. Tessie is able to be administered up to three times within 24 hours, with at least three hours in between each dose.
What Is Separation Anxiety in Dogs?
Separation anxiety is fear-based behavioral issues that present when a dog is left alone. According to ASPCA, common symptoms of separation anxiety in dogs includes:
- Urinating or defecating in the home
- Barking and howling
- Chewing, digging and destruction
- Escaping
- Pacing
While some separation anxiety can be treated with behavioral interventions and training, sometimes medications may be necessary. It's best to consult your vet for your specific situation to determine the best course of action for your pup.
Related: How to Build Trust With a Fearful Rescue Pet, According to a Vet
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This story was originally published May 8, 2026 at 12:20 PM.