Traffic on southbound Highway 101 was stopped Wednesday night after a sedan and a van collided head-on near San Luis Bay Drive.
At least three people were reportedly injured in the wreck, which occurred just before 9 p.m. Two ambulances as well as firefighers from Pismo and Avila Beach responded with CHP.
Firefighters used the jaws of life to remove the victim in the sedan.
One lane had opened by 9:30.
Additional information about the wreck was not immediately available.