Update, 10 a.m.
All lanes of southbound Highway 101 are back open, according to Caltrans.
One lane of southbound Highway 101 is closed Thursday morning after a pickup and a semi crashed near the Cuesta Grade, according to the California Highway Patrol
The crash happened just after 7:30 a.m. near Old Stage Coach Road, according to the CHP. The No. 3 lane was closed, which is the far-right lane of the highway. Caltrans tweeted that motorists should expect delays on their morning commute because of the crash.
Details, such as the number of people involved and the extent of injures, are currently unknown, but an ambulance was requested at the scene, according to the CHP.
This story will be updated.