Motorists should expect to detour Wednesday if they plan to use the northbound off-ramp of Highway 101 at Los Osos Valley Road.
The ramp will close from 8:30 a.m. to 3 p.m. Wednesday only, as the city of San Luis Obispo, assisted by Caltrans, re-stripes the overpass.
Drivers can use the Higuera Street exit to the south, or the Prado or Madonna Road exits to the north.
Electronic message boards will be posted along Hwy. 101 to alert motorists of the closure.