Patent medicine was a big part of a newspaper's income in the 1800s and early 1900s.
Salesmen have been selling "safe, reliable" pills for a long time. This ad is from Nov. 25, 1918.
Chichester's Pills claimed to be good for women's problems, though several websites say that the product's active ingredient, the herb pennyroyal, could be fatally toxic.
Not the best strategy for winning repeat customers.